#William barry nottingham trent university pdf#

The following PDF provides a brief visual summary of this group’s current research. Identifying the underlying immunological mechanisms that result in complications of stroke recovery could provide new therapeutic strategies to reduce these complications and improve outcome and long-term survival after stroke. My research uses integrated experimental animal and clinical studies, clinically relevant models of infection and vaccination, and epidemiological population health data analyses to understand the effect of stroke on the immune system and the immunological mechanisms that underpin complications of stroke recovery, such as increased infection risk. Learoyd, A.E., et al., Infections Up to 76 Days After Stroke Increase Disability and Death.Patel, A., et al., Executive summary Part 2: Burden of Stroke in the next 20 years and potential returns from increased spending on research, S.

Considering the danger of infection in both the acute and chronic phases of stroke recovery, little is known of the persistence of the changes to the immune system that occur acutely after stroke or how long stroke patients remain at increased risk of infection. Infections occurring at later time points after stroke are also associated with increased death and disability.

This may have an important role in increasing infections in stroke patients and we are investigating whether therapeutic targeting of this pathway may help to reduce this. We have identified deficits in innate-like B cells and circulating IgM antibody due to activation of the sympathetic nervous system and increased production of catecholamines after experimental stroke. Infection is a common and serious complication of stroke recovery.